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The role of receptor binding specificity in interspecies transmission of influenza viruses

Identifieur interne : 000A01 ( Main/Exploration ); précédent : 000A00; suivant : 000A02

The role of receptor binding specificity in interspecies transmission of influenza viruses

Auteurs : Masaki Imai [Japon] ; Yoshihiro Kawaoka [États-Unis, Japon]

Source :

RBID : PMC:5605752

Abstract

Influenza A virus infection begins with the binding of the hemagglutinin (HA) glycoprotein to sialic acid-containing receptors on the surface of the target cell. Avian influenza viruses, including avian H5N1, H7, and H9N2 viruses, can occasionally cross the species barrier and infect humans; however, these viruses do not spread efficiently from person to person, perhaps, in part, due to differences in the receptor-binding specificities of human and avian influenza viruses. The HAs of avian influenza viruses must adapt to receptors in humans to acquire efficient human-to-human transmissibility. In this review, we discuss the receptor binding specificity of influenza A viruses and its role in interspecies transmission.


Url:
DOI: 10.1016/j.coviro.2012.03.003
PubMed: 22445963
PubMed Central: 5605752


Affiliations:


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